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Letrozole Oral Tablet/Ribociclib Oral Tablet (RIBOCICLIB/LETROZOLE - ORAL)

For treating cancer.

Brand Name(s): Femara/Kisqali

Generic Name: Letrozole/Ribociclib

Instructions

Swallow the medicine without crushing or chewing it.

Keep the medicine in its original container.

This medicine may be taken with or without food.

This medicine will work best if you take it at about the same time every day.

Store at room temperature away from heat, light, and moisture. Do not keep in the bathroom.

Avoid grapefruit juice while on this medicine.

If you vomit after taking a dose, do not take an extra dose. Take your next dose at the usual time.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you forget a dose, just wait. Use the next dose at the usual time. Do not use 2 doses at once.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

This medicine may affect the strength of your bones. If you have or are at increased risk for osteoporosis (weakening of the bones), your doctor may recommend foods with calcium and vitamin D.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

This medicine should not be used in patients taking estrogen. The combination of the two medicines can increase the risk of serious side effects, including heart disease and blood clots. Speak with your doctor before taking any medicine containing estrogen.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

May cause mouth sores. Brush teeth gently. Avoid products containing alcohol. Rinse mouth with a mixture of water and baking soda or salt.

This medicine is associated with an increased risk of serious heart problems, heart attack, and stroke. Please speak with your doctor about the risks and benefits of using this medicine. Contact your doctor immediately if you experience chest pain or difficulty breathing.

This medicine is associated with an increased risk for serious blood clots. Speak with your doctor about the benefits and risks from using this medicine.

Do not use the medication any more than instructed.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

Please check with your doctor before drinking alcohol while on this medicine.

Avoid smoking while on this medicine. Smoking may increase your risk for bone fractures.

This medicine may reduce your body's ability to fight infections. Avoid contact with people with colds, flu or other infections. Contact your doctor if you develop fever, cough, sore throat, or chills.

Speak with your health care provider before receiving any vaccinations.

Do not breastfeed while on this medicine. You may safely start breastfeeding 3 weeks after stopping treatment.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Women of childbearing age should have a negative pregnancy test before starting this medicine.

Women must use reliable forms of birth control while taking this medicine and for 3 weeks after stopping to prevent pregnancy.

Women who are pregnant or in their childbearing years should not touch or handle this medicine. This medicine can be absorbed through the woman's skin and harm the unborn baby.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

  • agitated feeling or trouble sleeping
  • decreased appetite
  • back pain
  • diarrhea
  • drowsiness or sedation
  • lack of energy and tiredness
  • feeling of heat or flushing
  • hair loss
  • headaches
  • mouth sores or irritation
  • nausea and vomiting
  • sweating

Call your doctor or get medical help right away if you notice any of these more serious side effects:

  • blurry vision
  • bone pain
  • chest or jaw pain
  • cough that does not go away
  • dizziness
  • fainting
  • fever or chills
  • swelling in the neck or throat
  • numbness or tingling in hands and feet
  • severe or persistent headache
  • fast or irregular heart beats
  • sudden leg pain, swelling, warmth or redness
  • signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
  • mood changes
  • joint or muscle pain
  • shortness of breath
  • sore throat
  • symptoms of stroke (such as one-sided weakness, slurred speech, confusion)

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.